Bone Mass and Mineral Metabolism Alterations in Adult Celiac Disease: Pathophysiology and Clinical Approach
نویسندگان
چکیده
Osteoporosis affects many patients with celiac disease (CD), representing the consequence of calcium malabsorption and persistent activation of mucosal inflammation. A slight increase of fracture risk is evident in this condition, particularly in those with overt malabsorption and in postmenopausal state. The adoption of a correct gluten-free diet (GFD) improves bone derangement, but is not able to normalize bone mass in all the patients. Biomarkers effective in the prediction of bone response to gluten-free diet are not yet available and the indications of guidelines are still imperfect and debated. In this review, the pathophysiology of bone loss is correlated to clinical aspects, defining an alternative proposal of management for this condition.
منابع مشابه
Celiac Disease, Gluten-Free Diet, and Bone Mass Density
Background: Celiac disease (CD), as an autoimmune disease has initiated since ingestion of food containing gluten. Constant intolerance to gluten causes damages of the small intestinal mucosa. One reason of mal-absorption in children and infants is CD. Additionally, about 75% of newly identified patients with CD have low bone mineral density (BMD). Many factors have role in metabolic bone disea...
متن کاملLongitudinal changes in bone metabolism and bone mineral content in children with celiac disease during consumption of a gluten-free diet.
BACKGROUND A gluten-free diet (GFD) rapidly corrects the bone mineral deficit of children with untreated celiac disease. The mechanisms underlying such changes are still poorly understood. OBJECTIVE In a longitudinal study, we monitored changes in bone metabolism during consumption of a GFD. DESIGN We studied 22 white patients with celiac disease (11 girls) aged 10.5 +/- 1.0 y at the time o...
متن کاملPrevalence of Low Bone Mass for Chronological Age in Children with Acute Leukemia in Southern Iran
Background: Total bone mass acquired during childhood is known to be the most important determinant and base of lifelong skeletal health. The present study investigated the prevalence of low bone mass for chronological age (LBM) in lumbar and femoral areas of leukemic children in the south of Iran and evaluated the association of anthropometric, clinical and laboratory data of these children ...
متن کاملPrevalence of osteoporosis and vitamin D receptor gene polymor-phisms (FokI) in an Iranian general population based study (Kurdistan) (IMOS)
Background: Osteoporosis, or porous bone, is a disease characterized by low bone mass density (BMD) and structural deterioration of bone tissue, leading to bone fragility and increased risk of hip, spine, and wrist fractures. There are numerous risk factors for osteoporosis. While many of these factors are non-genetic in nature, there is a definite genetic component responsible for this condi...
متن کاملBody composition and calcium metabolism in adult treated coeliac disease.
Twenty two treated adult patients with coeliac disease (aged 20-70 years) were examined. Body composition was assessed from anthropometry and directly measured by dual photon absorptiometry. Bone mineral content was measured in the spine (dual photon absorptiometry) and at two forearm sites (single photon absorptiometry). Compared with age matched healthy subjects, treated coeliac patients had ...
متن کامل